The Adrenal Fatigue Prednisone Link - Fatigue to Flourish Sep 23, 2021 · The take away here – if you’re taking a glucocorticoid like prednisone adrenal fatigue is a definite risk. How to prevent adrenal fatigue To better prevent adrenal fatigue from prednisone use, we need to do two things: Take a better history; Have your cortisol levels tested before prescribing drugs like prednisone